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Drug Metabolism

* Drug Metabolism (aka ~ Pharmacogenetics)

* Testing

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Drug Interactions ~ Defining Genetic Influences on Pharmacologic Responses

Overview from website: This table is designed as a hypothesis testing, teaching and reference tool for physicians and researchers interested in drug interactions that are the result of competition for, or effects on the human cytochrome P450 system.
Substrates Table...

Drug Metabolism: Regulation & Importance
There are several short synopses by scientists from the Benson Symposia in Copenhagen. Symposia: No. 48 (2001)- The clinical importance of CYP enzymes relates to their numerous physiological functions and their role in drug metabolism.

CYP2D6: An Enzyme You Need to Know About
Article by Bruce Boyers March 17, 2003 - There are many different types of enzymes, but there is only one enzyme that primarily makes it possible to metabolize more than a quarter of all prescription drugs, including virtually all anti-depressants and ADHD treatments.

The link below is the main website for Pharmacogenetics:
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CYP2D6: An Enzyme You Need to Know About


Pharmacogenomics Testing
There have been cases regarding individuals who are given a certain therapeutic drug to treat symptoms or to keep symptoms from occurring in which the individual has a very violent reaction to the drug or feels no affect whatsoever.  Many times this happens because of the genetic makeup of the individual.  The study of this phenomenon is called “pharmacogenomics” or “pharmacogenetics.”


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